منابع مشابه
Notch signaling.
The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans. Studies on the expression, mutant phenotypes, and developmental consequences of unregulated receptor activation have implicated these proteins in a general mechanism of local cell signaling, which includes interactions between equivalent cells and...
متن کاملNotch signaling.
The Notch pathway regulates cell proliferation, cell fate, differentiation, and cell death in all metazoans. Notch itself is a cell-surface receptor that transduces short-range signals by interacting with transmembrane ligands such as Delta (termed Delta-like in humans) and Serrate (termed Jagged in humans) on neighboring cells (Fig. 1). Some soluble ligands have also been identified in Caenorh...
متن کاملThe Notch Transcription Activation Complex Makes Its Move
Two papers in this issue of Cell, (Nam et al., 2006; Wilson and Kovall, 2006) report the crystal structure of the Notch transcriptional activation complex. These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.
متن کاملThe Effect of Teachers' Follow-up Move Approach (F-move) on Iranian EFL Learners' Conversation Quality
The present paper investigated the effect of teacher’s follow‐up move approach on Iranian EFL learners’ conversation quality. Ninety students were selected in a senior high school in Poldokhtar, Iran. Through an oral test sixty out of ninety students whose scores were between one standard deviation (SD) above and below the mean were selected as the participants of the study. Then they were divi...
متن کاملNotch Signaling Components
Non-small-cell lung cancer (NSCLC) is a lethal and aggressive malignancy. Currently, the identities of prognostic and predictive makers of NSCLC have not been fully established. Dysregulated Notch signaling has been implicated in many human malignancies, including NSCLC. However, the prognostic value of measuring Notch signaling and the utility of developing Notch-targeted therapies in NSCLC re...
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ژورنال
عنوان ژورنال: Traffic
سال: 2007
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2007.00592.x